However, most people who start experimenting with substances will not become addicted, and the question remains why some, but not other, people develop problematic use. Prog Brain Res Repeated or chronic HPA axis activation by repeated stress or substance use can lead to impaired stress responses, including blunted impaired HPA axis activation or prolonged responses impaired HPA axis inhibition , and a lack of HPA axis habituation to repetition of the same stressor Int J Psychophysiol. However, people could be clustered according to equal attention allocation to smoking and naturally rewarding stimuli, versus diminished activation to naturally rewarding stimuli compared to smoking-related information. The influence of neighborhood disadvantage and perceived disapproval on early substance use initiation. People with trait-like elevated stress reactivity, negative affect and the belief that substances can improve mood or relief stress, increased risky behavior, poor decision making skills, or impaired behavioral control and higher impulsivity may be at particular risk for stress-induced initiation.
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